Ro 31-8220 Mesylate CAS:138489-18-6

Ro 31-8220 is a PKC-inhibitor,which inhibits stimulated fluid pinocytosis of human PMNs induced by the PKC-activators phorbol myristate acetate (PMA,IC50=1.35 x 10(-6)M)or diacylglycerols(OAG,diC8)by 95%.Ro-31-8220 showed the apoptotic effect on HL-60 cells,which was mediated by a well-characterized transduction process of apoptotic signals:i.e.,mitochondrial cytochrome c efflux and the activation of caspase-3 in the cytosol. 

msds---Ro 31-8220 Mesylate